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							<h2 id="t_1304649a30102wkkr" class="titName SG_txta">真相：网传吃姜会得肝癌，事实是什么？</h2>
			
					<span class="time SG_txtc">(2016-06-12 15:39:17)</span><div class="turnBoxzz"><a href="javascript:;" class="SG_aBtn SG_aBtn_ico SG_turn"  action-type="reblog" action-data="{srcBlog:1, blogId:'1304649a30102wkkr'}"><cite><img class="SG_icon SG_icon111" src="http://simg.sinajs.cn/blog7style/images/common/sg_trans.gif" width="15" height="15" align="absmiddle">转载<em class="arrow">▼</em></cite></a></div>		</div>
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（作者：乐乐博士&nbsp;<wbr><strong STYLE="margin: 0px; padding: 0px; white-space: pre-wrap; box-sizing: border-box !important;">临床肿瘤专科医师</STRONG>）</STRONG></DIV>
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姜是我们最常用的做菜佐料之一，也是普遍认为具有保健作用的食品。然而，最近有小伙伴反映，他们在美国食品药物管理局（FDA）的研究里面发现，生姜里含有的黄樟素可引起肝癌，在小鼠的饲料中添加0.04%～1%的黄樟素，在150天到2年的时间里，会诱导小鼠产生肝癌。<span STYLE="margin: 0px; padding: 0px; font-family: 微软雅黑; box-sizing: border-box !important;">这也太可怕了吧！</SPAN></SPAN></P>
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肝癌号称“癌症之王”，预后极差，人人都谈之色变，写下“既然选择了远方，便只顾风雨兼程”的著名诗人汪国真就是被肝癌带走的。还让不让人愉快地吃姜了？！<span STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;">各位稍安勿躁，我们接下来就看看，到底肝癌是怎么回事、什么样的因素会导致肝癌、还有吃姜究竟会不会诱发肝癌。</SPAN></P>
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首先，我们来认识认识肝癌</H2>
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我们的肝脏主要由肝细胞和胆管上皮细胞组成，发生于这两种细胞的癌症都叫做肝癌。肝癌分为肝细胞癌、胆管细胞癌和混合细胞癌（即两种细胞都发生了癌变）<span STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;">三种类型</SPAN>。</P>
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在我国，与肝癌相关的危险因素主要包括肝炎病毒感染、食物黄曲霉素污染、长期酗酒以及农村饮水蓝绿藻类毒素污染。</P>
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其中，慢性乙型肝炎是最重要、也是最明确的危险因素。当乙型肝炎病毒感染了我们的肝细胞以后，病毒就可能会整合到肝细胞的遗传物质中去，就跟穷亲戚搬进家里一样，从此赖着不走。不仅如此，它们还会在肝细胞里面生息繁衍，释放后代感染更多的肝细胞。被感染的肝细胞表明会表达病毒的标志，我们身体的免疫系统识别到这些标志，就会认为这个肝细胞已经被敌人控制了，必须派出免疫细胞将其消灭。借刀杀人，这就是乙肝导致肝损害的原理。</P>
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更麻烦的是，如果病毒和肝细胞两者的遗传物质整合到一起的话，单靠免疫系统很难将之清除，所以乙肝自然转阴的病例是很少很少的。</P>
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如果肝细胞长期处于这种损伤、修复的循环，再生的细胞就会逐渐失去原来正常的结构和功能，发展为肝硬化，进而发展为肝癌。中国是著名的肝炎大国，目前卫计委公布的乙肝患者和携带者数量大概在1亿左右，无论是数量还是比例都是世界之最。“肝炎——肝硬化——肝癌”三部曲，是中国肝癌高发的最主要原因。</P>
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除此之外，不良的饮食习惯也是诱发肝癌的原因。黄曲霉一般产生于各自发霉的食物，尤其是坚果如花生、核桃、玉米、通心粉、调味品、牛奶、奶制品、食用油等制品之中。这种真菌会释放黄曲霉素，这是一种1级致癌物，致癌作用极强，与肝癌的关系非常密切。还有，农村饮用被蓝绿藻类污染的水源也可能增加肝癌的风险。</P>
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另外，肝癌还与年龄、性别有关系。肝癌的高发年龄是50~60岁，男性要明显高于女性。</P>
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吃姜会导致肝癌吗？</H2>
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这个传言的出现主要是源于美国FDA的一份研究：黄樟素可引起肝癌，黄樟素经过代谢转化为活性致癌物的过程，目前已经比较清楚：黄樟素在小鼠体内首先代谢为苯乙醇形式，接着被激活转化为乙酸盐或硫酸盐，成为最终的致癌物。黄樟素若与氧化剂结合，会生成更强致癌活性的环氧黄樟素。在小鼠的饲料中添加0.04%～1%的黄樟素，150天到2年，可诱导小鼠产生肝癌。</P>
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黄樟素主要存在于黄樟油、大叶樟油、南美巴西黄樟油、北美黄樟油等天然芳香油中，这些原料可能会被用于制作食用天然香精。另外，在生姜、豆蔻、月桂等佐料里面也含有少量黄樟素。国际食品添加剂法典委员会正在启动制定的《食用香料使用准则》中规定，黄樟素在食品和饮料中最大限量为1毫克/千克。</P>
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如此看来，“吃姜可能导致肝癌”这个传言是有一定依据和道理的。但是，如果因此就拒绝吃姜，那也未免有些矫枉过正。<span STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;">首先，黄樟素是2类致癌物，它的致癌作用远没有黄曲霉素强。其次，没有发霉的生姜所含的黄樟素很少，如果只是做菜偶尔放一些，是远远不会达到1毫克/千克的警戒线的。不过，我们还是要注意，不要拿它当饭吃、天天吃，另外，发霉的生姜一定要丢掉，因为里面的黄樟素含量会大大增高。</SPAN></P>
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怎样才能预防肝癌？<span STYLE="margin: 0px; padding: 0px; color: rgb(62, 62, 62); box-sizing: border-box !important;">&nbsp;<wbr></SPAN></H2>
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比起不吃姜，我们还有更多靠谱得多的预防措施可以执行——</P>
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1</SPAN><strong STYLE="margin: 0px; padding: 0px; border-color: rgb(89, 195, 249); color: inherit; box-sizing: border-box !important;">全面推广乙肝疫苗的接种</STRONG></H2>
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现在乙肝疫苗一般都是出生常规接种的，但是还有少部分地区没有严格执行。出生接种的乙肝疫苗一般可以管15-20年左右，如果过了这段时间，复查抗体滴度太低的话，建议再次接种补强疫苗。此外，如果不幸查出患了慢性肝炎，一定要主动接受治疗。<br STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;" />
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2</SPAN><strong STYLE="margin: 0px; padding: 0px; border-color: rgb(89, 195, 249); color: inherit; box-sizing: border-box !important;">不能食用霉变食物、远离烟酒和高脂饮食</STRONG></H2>
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使用可靠水源也是帮助我们预防肝癌的主要手段。<span STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;">花椰菜、洋葱、海藻、蓝莓等食物可能具有一定的抗癌作用。多吃蔬菜水果也有助于减轻黄樟素的毒性作用。</SPAN><span STYLE="margin: 0px; padding: 0px; box-sizing: border-box !important;">中国肝癌指南建议，对于≥40岁的男性或≥50岁女性，具有乙肝和/或丙肝感染、嗜酒、合并糖尿病以及有肝癌家族史的高危人群，每隔6个月进行一次AFP（甲胎蛋白）
腹部超声检查，争取早期发现。对于一般人群，指南没有建议做常规筛查，只要每年定期体检就足够了。</SPAN></P>
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由此可见，姜只要做到适量，还是可以放心让它成为餐桌上的一个好配角的。身为广东人的我自己也觉得，蒸鱼要是没有了姜和葱，这道菜就是不完整的。反而，我们更应该注意肝癌的其他危险因素，比如肝炎、发霉的食物等等。远离它们，才是帮助我们远离肝癌更为行之有效的途径。</P>
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